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Zenchent与食物

Zenchent与食物安全配伍检测的结果。

检测结果:
Zenchent <> 食物
现实性: 03.07.2019 评论家: 医学副博士Shkutko P.M., in

通过权威的信息来源 Drugs.com、Rxlist.com、Webmd.com、Medscape.com,在进行所选药物与这种食物或生活方式互相作用检测时,发现一些会产生负面影响或对身体危害的禁忌症及副作用。

用户:

消费者信息对于这种相互作用是目前不可用。

医界专家:

监视器:柚子汁可能增加等离子浓度的口服给药品是基底的CYP450 3A4同工酶. 拟议的机制是抑制CYP450 3A4介导的第一次通过新陈代谢的肠道墙的某些化合物的存在柚子。 因为柚子汁抑制主要是肠道,而不是肝CYP450 3A4,幅度相互作用是最大的那些药物,经历显着的前系統的新陈代谢通过CYP450 3A4(即,药物具有生物利用度低的口服). 在一般情况下,效果的葡萄汁是浓度、剂量和准备的依赖,并可能广泛变化之间的品牌。 某些筹备工作的柚子汁(例如,高剂量、双重力量)有时会表现出强有力的抑制作用CYP450 3A4,而其他的筹备工作(例如,低剂量,单个的强度)通常表明的适度的抑制作用。 药物动力学的相互作用涉及柚子汁也受到高度病人間的可变性,因此在多大程度上给予病人可能会受到影响难以预测。

管理:患者,经常食用柚子或柚子汁应监测的不利影响和改变的等离子浓度的药物进行重大前系統的新陈代谢通过CYP450 3A4. 柚子和柚子汁应该可以避免的,如果互动是怀疑。 橙汁不是预期与这些药物。

来源
  • Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41
  • Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8
  • Bailey DG, Dresser GR, Kreeft JH, Munoz C, Freeman DJ, Bend JR "Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients." Clin Pharmacol Ther 68 (2000): 468-77
  • Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32
  • Libersa CC, Brique SA, Motte KB, et al. "Dramatic inhibition of amiodarone metabolism induced by grapefruit juice." Br J Clin Pharmacol 49 (2000): 373-8
  • Bailey DG, Malcolm J, Arnold O, Spence JD "Grapefruit juice-drug interactions." Br J Clin Pharmacol 46 (1998): 101-10
  • "Grapefruit juice interactions with drugs." Med Lett Drugs Ther 37 (1995): 73-4
  • Bailey DG, Kreeft JH, Munoz C, Freeman DJ, Bend JR "Grapefruit juice felodipine interaction: Effect of naringin and 6',7'-dihydroxybergamottin in humans." Clin Pharmacol Ther 64 (1998): 248-56
  • Jonkman JH, Sollie FA, Sauter R, Steinijans VW "The influence of caffeine on the steady-state pharmacokinetics of theophylline." Clin Pharmacol Ther 49 (1991): 248-55
  • Ozdemir M, Aktan Y, Boydag BS, Cingi MI, Musmul A "Interaction between grapefruit juice and diazepam in humans." Eur J Drug Metab Pharmacokinet 23 (1998): 55-9
  • Takanaga H, Ohnishi A, Maatsuo H, et al. "Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model." Br J Clin Pharmacol 49 (2000): 49-58
  • Lilja JJ, Kivisto KT, Neuvonen PJ "Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin." Clin Pharmacol Ther 66 (1999): 118-27
  • Eagling VA, Profit L, Back DJ "Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-I protease inhibitor saquinavir by grapefruit juice components." Br J Clin Pharmacol 48 (1999): 543-52
  • Lee AJ, Chan WK, Harralson AF, Buffum J, Bui BCC "The effects of grapefruit juice on sertraline metabolism: An in vitro and in vivo study." Clin Ther 21 (1999): 1890-9
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  • Min DI, Ku YM, Geraets DR, Lee HC "Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers." J Clin Pharmacol 36 (1996): 469-76
  • Bailey DG, Arnold JM, Munoz C, Spence JD "Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin." Clin Pharmacol Ther 53 (1993): 637-42
  • Sigusch H, Hippius M, Henschel L, Kaufmann K, Hoffmann A "Influence of grapefruit juice on the pharmacokinetics of a slow release nifedipine formulation." Pharmazie 49 (1994): 522-4
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Zenchent

非专利名称: ethinyl estradiol / norethindrone

品牌: Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

同义词: Zenchent (birth control)

Zenchent <> 食物
现实性: 03.07.2019 评论家: 医学副博士Shkutko P.M., in

通过权威的信息来源 Drugs.com、Rxlist.com、Webmd.com、Medscape.com,在进行所选药物与这种食物或生活方式互相作用检测时,发现一些会产生负面影响或对身体危害的禁忌症及副作用。

用户:

消费者信息,对这个轻微的相互作用目前不可用。 一些轻微的药物相互作用可能不是临床相关的所有患者。 轻微的药物相互作用通常不会造成伤害或需要改变治疗。 然而,你的医疗保健提供者可以确定,如果调整到你的药物是必要的。

医界专家:

共同给予有柚子汁可能增加的生物利用率的口头雌激素。 拟议的机制是抑制CYP450 3A4介导的第一次通过新陈代谢的肠壁致通过某些化合物存在于葡萄柚。 在一个小型的,随机的,交叉研究,政府的乙炔雌二醇与柚子汁(比较凉茶)增加的峰值等离子体药物的浓度(C)通过37%和面积的浓度时间曲线(AUC)的28%。 根据这些调查结果、葡萄汁是不太可能影响总的安全情况的炔雌二醇。 然而,与其他药物的相互作用涉及柚子汁、药物代谢动力学的改变都受到了高度的病人間的可变性。 此外,影响其他的雌激素没有被研究。

来源
  • Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24
  • Weber A, Jager R, Borner A, et al. "Can grapefruit juice influence ethinyl estradiol bioavailability?" Contraception 53 (1996): 41-7
Zenchent

非专利名称: ethinyl estradiol / norethindrone

品牌: Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

同义词: Zenchent (birth control)

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